• World Neurosurg · May 2021

    Clinical characteristics of ruptured intracranial aneurysm in patients with multiple intracranial aneurysms.

    • Hiroki Sato, Tomoya Kamide, Yuichiro Kikkawa, Tatsuki Kimura, Seiji Kuribara, Taro Yanagawa, Kaima Suzuki, Toshiki Ikeda, and Hiroki Kurita.
    • Department of Neurosurgery, International Medical Center, Saitama Medical University, Hidaka, Japan.
    • World Neurosurg. 2021 May 1; 149: e935-e941.

    ObjectiveIt is difficult to correctly identify the ruptured aneurysm in patients with multiple intracranial aneurysms. Here, we investigated the clinical characteristics of ruptured intracranial aneurysms in such patients.MethodsWe retrospectively analyzed 361 patients who underwent microsurgical clipping of ruptured intracranial aneurysms at our institution from 2012 to 2018. Patients' age, sex, Fisher group, World Federation of Neurosurgical Societies grade, size (neck width, depth, maximum diameter), location, and shape of intracranial aneurysm, and hemorrhage pattern on admission were reviewed.ResultsIn total, 266 patients (74%) had single intracranial aneurysms and 95 (26%) had multiple intracranial aneurysms. Eighty-nine of the 95 multiple intracranial aneurysms (94%) had irregular shape (P < 0.01). The median aspect ratios of ruptured and unruptured intracranial aneurysms were 2.2 ± 1.1 and 1.0 ± 0.4, respectively (P < 0.01). Twelve of 95 patients (13%) had ruptured intracranial aneurysms that were smaller than unruptured intracranial aneurysms. Among the 12 patients, the aspect ratios of ruptured intracranial aneurysms were greater than those of unruptured intracranial aneurysms (P < 0.01). Regarding morphologic characteristics, aspect ratio, maximum size, and irregular shape could be the useful predictive factors, but the greatest aspect ratio among patients with multiple aneurysms was the most predictive of an intracranial aneurysm rupture, after adjustment for aneurysmal size (adjusted odds ratio 217.82; 95% confidence interval 56.41-841.08).ConclusionsThe results of this study indicate that the aspect ratio is the most predictive factor of a ruptured intracranial aneurysm in patients with multiple intracranial aneurysms.Copyright © 2021 Elsevier Inc. All rights reserved.

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