• Meng Zhang, Lingyan Zhou, Jing Wang, Kun Wang, Yuan Wang, Xudong Pan, and Aijun Ma.
• Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
• J Clin Neurosci. 2020 Dec 1; 82 (Pt A): 87-92.

AbstractIn December 2019, COVID-19 outbroke in Wuhan, then sweeping the mainland of China and the whole world rapidly. On March 4, Beijing Ditan Hospital confirmed the existence of SARS-CoV-2 in the cerebrospinal fluid by gene sequencing, indicating the neurotropic involvement of SARS-CoV-2. Meanwhile, neurological manifestations in the central nervous system, peripheral nervous system and skeletal muscular were also observed, indicating the potential neuroinvasion of SARS-CoV-2. In particular, we focused on its neurological manifestations and specific pathogenesis, as well as its comparison with other viral respiratory infections. Finally, we further summarized the significance of the neuroinvasion and the follow-up issues that need to be paid attention to by scientists, so as to help neurologists understand the influence of SARS-CoV-2 on nervous system better and promote the accurate diagnosis and efficient treatment of COVID-19.Copyright © 2020 Elsevier Ltd. All rights reserved.

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