• Medicina · Feb 2021

    Review

    Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance during General Anesthesia-A New Era in Patient Safety Standards and Healthcare Management.

    • Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Marius Papurica, Sonia Elena Popovici, Lavinia Melania Bratu, Andreea Rata, Claudiu Rafael Barsac, Andra Maghiar, Dragos Nicolae Garofil, Mihai Negrea, Laura Bostangiu Petcu, Daiana Toma, Corina Maria Dumbuleu, Samir Rimawi, and Dorel Sandesc.
    • Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
    • Medicina (Kaunas). 2021 Feb 2; 57 (2).

    AbstractThe development of general anesthesia techniques and anesthetic substances has opened new horizons for the expansion and improvement of surgical techniques. Nevertheless, more complex surgical procedures have brought a higher complexity and longer duration for general anesthesia, which has led to a series of adverse events such as hemodynamic instability, under- or overdosage of anesthetic drugs, and an increased number of post-anesthetic events. In order to adapt the anesthesia according to the particularities of each patient, the multimodal monitoring of these patients is highly recommended. Classically, general anesthesia monitoring consists of the analysis of vital functions and gas exchange. Multimodal monitoring refers to the concomitant monitoring of the degree of hypnosis and the nociceptive-antinociceptive balance. By titrating anesthetic drugs according to these parameters, clinical benefits can be obtained, such as hemodynamic stabilization, the reduction of awakening times, and the reduction of postoperative complications. Another important aspect is the impact on the status of inflammation and the redox balance. By minimizing inflammatory and oxidative impact, a faster recovery can be achieved that increases patient safety. The purpose of this literature review is to present the most modern multimodal monitoring techniques to discuss the particularities of each technique.

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