• Hao Le, Lianjun Wang, Lan Zhang, Pengfei Chen, Bin Xu, Dengfa Peng, Ming Yang, Yong Tan, Changsong Cai, Huqing Li, and Qiu Zhao.
• First Department of Surgery.
• Medicine (Baltimore). 2021 Jan 22; 100 (3): e23934.

BackgroundConventional white-light imaging endoscopy (C-WLI) had a significant number of misdiagnosis in early gastric cancer (EGC), and magnifying endoscopy (ME) combined with different optical imaging was more accurate in the diagnosis of EGC. This study aimed to evaluate the accuracy of ME and compare the accuracy of ME with different optical imaging in detecting EGC.MethodsA comprehensive literature search was conducted to identify all relevant studies. Pair-wise meta-analysis was conducted to evaluate the accuracy of ME, and Bayesian network meta-analysis was performed to combine direct and indirect evidence and estimate the relative effects.ResultsEight prospective studies were identified with a total of 5948 patients and 3 optical imaging in ME (ME with WLI (M-WLI), ME with narrow-band imaging (M-NBI), and ME with blue laser imaging (M-BLI)). Pair-wise meta-analysis showed a higher accuracy of ME than C-WLI (OR: 2.97, 95% CI: 1.68∼5.25). In network meta-analysis, both M-NBI and M-BLI were more accurate than M-WLI (OR: 2.56, 95% CI: 2.13∼3.13; OR: 3.13, 95% CI: 1.85∼5.71). There was no significant difference between M-NBI and M-BLI.ConclusionME was effective in improving the detecting rate of EGC, especially with NBI or BLI.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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