-
- Hongbing Ma and Hong Chang.
- Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
- Medicine (Baltimore). 2021 Jan 22; 100 (3): e24025.
RationaleAcquired hemophilia A (AHA) is a rare bleeding disorder with prolonged activated partial thromboplastin time (aPTT). Severe hemorrhage may occur, especially in refractory AHA.Patient ConcernsWe reported a 63-year-old man who suffered from life-threatening bleeding after the onset in lower limbs.DiagnosesThe patient was diagnosed as AHA which was related to pemphigoid.InterventionsThe patient had no response to the first-line treatment with corticosteroid and cyclophosphamide. Meanwhile, fatal hemorrhage occurred successively in thoracic cavity and right frontal lobe. rFVIIa and rituximab were administered.OutcomesThe patient survived from the life-threatening hemorrhage with a normal aPTT. His aPTT and FVIII:C level was normal during the follow-up of 6 months.LessonsRituximab and rFVIIa can play a critical role in rescuing AHA that is refractory to the first-line treatment.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..