• Jiang Liu, Jing Cheng, Hongjun Zhou, Chunyan Deng, and Zhengxin Wang.
• Center for Neurological Diseases, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.
• Medicine (Baltimore). 2021 Jan 22; 100 (3): e24213.

IntroductionHypertensive intracerebral hemorrhage (HICH) is the most serious complication of hypertension. Clearing intracranial hematoma as soon as possible, reducing brain cell edema, and controlling intracranial pressure could effectively reduce neuron damage, lower patient mortality, and improve patient prognosis. At present, minimally invasive surgery (MIS) has been widely used and plays an important role in the treatment of HICH. However, it is still in controversies about the choice of surgical treatment and medication treatment for HICH. Therefore, we try to conduct a randomized, controlled, prospective trial to observe the efficacy of MIS treatment against HICH compared with medication treatment.MethodsPatients will be randomly divided into treatment group and control group in a 1:1 ratio using the random number generator in Microsoft Excel. Stereotactic soft channel minimally invasive intracranial hematoma puncture and drainage treatment and medication treatment will be applied respectively. The outcomes of intracerebral hemorrhage volume, Glasgow coma scale, National Institutes of Health Stroke Scale will be recorded.ConclusionsThe findings of the study will be helpful for the choice of MIS and conservative treatment when treating HICH patients.Trial RegistrationOSF Registration number: DOI 10.17605/OSF.IO/ME6Y5.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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