• Tao Li, Xinyu Wang, Chen Chen, Xiaobin Song, Jiannan Li, Zeyun Zhao, Nan Zhang, Wei Li, Kai Zhang, and Tongjun Liu.
• Department of Colorectal and Anal Surgery, the Second Hospital of Jilin University, Changchun.
• Medicine (Baltimore). 2021 Jan 22; 100 (3): e24378.

RationalePrimary periampullary duodenal cancer accounts for 3% to 17% of periampullary cancers. There are no previous reports of metachronous primary colon and periampullary duodenal cancer.Patient ConcernsWe present a case of primary periampullary duodenal cancer that occurred metachronously after colon cancer.DiagnosesImaging and endoscopic examinations, serum tumor marker levels, and pathology confirmed metachronous colon and periampullary duodenal cancer, with 14-month interval between the diagnoses of the 2 malignancies.InterventionThe patient received right hemicolectomy combined with mFOLFOX6 chemotherapy for colon cancer and pancreatoduodenectomy for periampullary duodenal cancer.OutcomesThe patient has been followed up for 6 years since the pancreatoduodenectomy and shows no signs of recurrence or metastasis.LessonsThe risk of developing a second malignancy may be associated with the site of the first tumor. Patients with right colon cancer may have particularly high risk of developing small intestinal cancer, including duodenal cancer. Early detection and active surgical treatments can improve prognosis. Long-term regular follow-up is necessary to detect new malignancies occurring after the diagnosis colon cancer.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

29 keywords...

hide…