• Ping Sui, Xiaoyan Wang, Lipeng Sun, and Hui Wang.
• Ultrasound Department of the First Affiliated Hospital of Dalian Medical University, Liaoning Province, China.
• Medicine (Baltimore). 2021 Jan 22; 100 (3): e24411.

BackgroundSuperb microvascular imaging (SMI) is a new ultrasound vascular imaging technology, which uses a new Doppler algorithm, it has the characteristics of high sensitivity and high resolution to detect low velocity blood flow; it is easier to detect microvessels with low-velocity flow compared with color Doppler flow imaging in theory; and it can image the microvessels of the lesion without angiography.[1] Previous studies showed that SMI can detect tumor neovascularization to differentiate benign from malignant focal liver lessions (FLLs). However, the results of these studies have been contradictory with low sample sizes. This meta-analysis tested the hypothesis that SMI is accurate in distinguishing benign and malignant FLLs.MethodsWe will search PubMed, Web of Science, Cochrane Library, and Chinese biomedical databases from their inceptions to the November 30, 2020, without language restrictions. Two authors will independently carry out searching literature records, scanning titles and abstracts, full texts, collecting data, and assessing risk of bias. Review Manager 5.2 and Stata14.0 software will be used for data analysis.ResultsThis systematic review will determine the accuracy of SMI in the differential diagnosis between benign and malignant FLLs.ConclusionIts findings will provide helpful evidence for the accuracy of SMI in the differential diagnosis between benign and malignant FLLs.Systematic Review RegistrationINPLASY2020120081.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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