• Jain Samit S SS Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxman Nair Hospital., Dharmesh K Shah, Pravir A Gambhire, Ravi U Varma, Qais Q Contractor, and Rathi Pravin M PM Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxman Nair Hospital..
• Department of Gastroenterology, Topiwala National Medical College and Bai Yamunabai Laxman Nair Hospital.
• J Dig Dis. 2015 Nov 1; 16 (11): 656-64.

ObjectiveTo study the extent of early atherosclerosis in ulcerative colitis (UC) patients by measuring carotid intima-media thickness (CIMT) and the correlation between CIMT, serum homocysteine level and homeostasis model assessment-insulin resistance (HOMA-IR) in UC.MethodsWe studied 60 UC patients and 60 healthy controls. Individuals with risk factors for atherosclerosis were excluded from the study. Fasting blood glucose, lipid profile, HOMA-IR, erythrocyte sedimentation rate (ESR), serum vitamin B12 and homocysteine levels were measured in all participants. CIMT was measured using a B-mode duplex imaging study.ResultsUC patients had significantly higher CIMT than controls (P < 0.05). ESR, fasting insulin, HOMA-IR and serum homocysteine levels were also significantly higher in UC patients (P < 0.05). Pearson's correlation coefficient showed significant correlations between: (i) CIMT and patients' age, duration of UC, HOMA-IR, and homocysteine level (P < 0.05); (ii) serum homocysteine and duration of UC, fasting insulin level, HOMA-IR and CIMT (P < 0.01); (iii) HOMA-IR and age, duration of UC, serum homocysteine and CIMT (P < 0.01). Multi-regression models showed that serum homocysteine affects CIMT and duration of UC independently, whereas participants' age and duration of UC affects HOMA-IR independently.ConclusionsHigher CIMT might indicate subclinical atherosclerosis in UC patients. Patients' age, duration of UC, HOMA-IR and homocysteine levels are important factors associated with increased CIMT.© 2015 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

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