• Medicina · Jan 2020

    Case Reports

    [Immunohistochemical analysis for the diagnosis of solitary fibrous tumor/ hemangiopericytoma].

    • Alejandra González Roffo, José I Gómez Escalante, Néstor Banfi, Ana Lía Nocito, Alejandra Báez, and Ignacio Casas Parera.
    • Departamento de Neurología, Centro Universitario de Neurooncología, Instituto de Oncología ángel H. Roffo, Facultad de Medicina, Universidad de Buenos Aires, Argentina. E-mail: neurooncologiainstitutoroffo@gmail.com.
    • Medicina (B Aires). 2020 Jan 1; 80 (6): 729-733.

    AbstractThe solitary fibrous tumor/ hemangiopericytoma (TFS/HP) is a rare mesenchymal extraaxial tumour. TFS/HP can sometimes be difficult to distinguish from other extra-axial tumors like meningioma, which can be clinically and radiologically indistinguishable. Molecular analysis with STAT6 (signal transducer and activator of transcription 6) nuclear expression or NAB2-STAT6 (NGFI-A binding protein 2) fusion is recommended to confirm the diagnosis. We present 3 cases, 2 women and 1 male, with pathological diagnosis of meningothelial meningioma in the first case; cases 2 and 3 with radiological suspicion of meningioma. The pathological review with molecular study certified the diagnosis of TFS/HP. For differential diagnosis between meningeal TFS/HP and meningioma, it is recommended to look for STAT6 expression as a first step, or NAB2-STAT6 fusion in order to confirm TFS/HP. The review of biopsy samples must be guaranteed in all patients, including those who were studied in Pathology Services Level 3.

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