• Bin Wang, Li Wang, Xianggen Kong, Jin Geng, Di Xiao, Chunhong Ma, Xue-Mei Jiang, and Pei-Hui Wang.
• Jinan Infectious Diseases Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
• J. Med. Virol. 2020 Sep 1; 92 (9): 1684-1689.

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection needs to be determined. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SARS-CoV-2 and virus-specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient who did not produce any SARS-CoV-2-bound IgG successfully cleared SARS-CoV-2 after 46 days of illness, revealing that without antibody-mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS-CoV-2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS-CoV-2 clearance, especially in nonsevere cases.© 2020 Wiley Periodicals, Inc.

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