• Pak J Med Sci · Mar 2021

    Effect of Dexmedetomidine Hydrochloride on perioperative inflammation and postoperative lung infection in patients with spinal tuberculosis.

    • Yong-Hui Liu, Ye Zhao, Xiang-Yang Wang, and Hong-Xun Cui.
    • Yong-hui Liu, Department of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, P.R. China, Department of Orthopedics, Orthopedic Hospital of Henan Province, Luoyang, Henan 471000, P.R. China.
    • Pak J Med Sci. 2021 Mar 1; 37 (2): 520-524.

    ObjectiveTo explore the effect of dexmedetomidine hydrochloride on perioperative inflammation and postoperative lung infection in patients with spinal tuberculosis.MethodA double-blind control observation was conducted in spinal tuberculosis patients with the use of general anesthesia during the operation. A total of 171 spinal tuberculosis patients who received endotracheal intubation for general anesthesia in Henan University of Chinese Medicine from January 2017 to April 2019 were included. The concentration changes in serum TNF-α and IL-6 were recorded at one hour, six hour and one day after the operation. The incidence of postoperative pulmonary complications of patients were also evaluated.ResultsThe results showed that in the experimental group compared with the control group, serum TNF-α and IL-6 concentrations one hour, six hour and one day after the operation were significantly lower (P<0.05). The rate of postoperative pulmonary complications was lower in the experimental group than that in the control group (P<0.05).ConclusionDexmedetomidine hydrochloride has obvious anti-inflammatory effects and can reduce the incidence of pulmonary complications after surgery.Copyright: © Pakistan Journal of Medical Sciences.

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