• Trans. R. Soc. Trop. Med. Hyg. · Aug 2013

    Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels.

    • Fernanda Salles, Andrea Bacellar, Mirla Amorim, Glória Orge, Michael Sundberg, Márcia Lima, Silvane Santos, Aurélia Porto, and Edgar Carvalho.
    • Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
    • Trans. R. Soc. Trop. Med. Hyg. 2013 Aug 1; 107 (8): 526-9.

    BackgroundHuman T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL).MethodsWe compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection.ResultsLevels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis.ConclusionThese data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL.

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