• Internal medicine · Jan 2021

    Hypoglycemia during the Concomitant Use of Repaglinide and Clopidogrel in an Elderly Patient with Type 2 Diabetes and Severe Renal Insufficiency.

    • Kana Takayama, Kohei Fujii, Hiroki Yamaguchi, Yumika Miyoshi, Yuhei Uehara, Shimpei Nagata, Yoshinari Obata, Motohiro Kosugi, Yoji Hazama, and Tetsuyuki Yasuda.
    • Department of Diabetes and Endocrinology, Osaka Police Hospital, Japan.
    • Intern. Med. 2021 Jan 1; 60 (6): 905-910.

    AbstractHypoglycemia should be avoided when treating patients with diabetes. Repaglinide is an insulin secretagogue with a low hypoglycemic risk because of its rapid- and short-acting effects. However, its blood concentration has been reported to increase in combination with clopidogrel, an antiplatelet drug, and in patients with severe renal insufficiency. We herein report an elderly patient with type 2 diabetes mellitus and severe renal insufficiency who received repaglinide and hypoglycemia three days after starting clopidogrel. The concomitant use of repaglinide and clopidogrel can lead to hypoglycemia, especially in patients with severe renal insufficiency.

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