• Pharmacotherapy · Jul 1996

    Case Reports

    Propylene glycol: the safe diluent that continues to cause harm.

    • M L Glover and M D Reed.
    • Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106-6010, USA.
    • Pharmacotherapy. 1996 Jul 1; 16 (4): 690-3.

    AbstractPropylene glycol (PG) is present in many pharmaceutical products, lotions, ointments, and cosmetics. Although considered to be a relatively safe substance, overdoses have been associated with serious adverse effects. Propylene glycol intoxication occurred in a child and caused central nervous system depression and a severe metabolic acidosis. Initial assessment revealed an elevated serum anion gap, a slight increase in measured serum osmolality, and a normal osmolal gap. The child's acidosis was due to increased concentrations of lactate and pyruvate. The possibility of serious PG intoxication should be considered in any patient with an unexplained serious metabolic acidosis.

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