• Heshmatzadeh BehzadiAshkanA0000-0002-2163-3662Department of Radiology, Yale New Haven, Bridgeport Hospital, Connecticut., Behzad Amoozgar, Shalini Jain, Noel Velasco, Umar Zahid, Hamidreza Abbasi, Lutfi Alasadi, and Martin R Prince.
• Department of Radiology, Yale New Haven, Bridgeport Hospital, Connecticut.
• Medicine (Baltimore). 2021 Mar 12; 100 (10): e24603e24603.

ObjectivesThis systematic review and meta-analysis assesses the utility of trimetazidine (TMZ) to prevent contrast induced nephropathy (CIN) in patients with renal insufficiency undergoing coronary angiography and angioplasty.Materials And MethodsThis meta-analysis was formulated and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search of databases was conducted by 2 researchers independently for clinical trials, comparing hydration plus TMZ vs conventional hydration alone for prevention of CIN through January 2020. All patients had renal insufficiency (defined as GFR < 89 ml/minute/1.73 m2) and the outcome of interest was the incidence of contrast induced acute kidney injury. The odds ratio (OR) was estimated with 95% confidence interval (CI). Heterogeneity was reported with the I2 statistic, using a fixed-effects model, and >50% of I2 was considered to be statistically significant.ResultsEleven studies, 1611 patients, met the inclusion/exclusion criteria: 797 patients comprised the TMZ plus hydration group and the remaining 814 patients comprised the control (hydration only) group. Heterogeneity was low I2 = 0%, P = .84, and the heterogeneity of each study was also low. The incidence of CIN in the TMZ plus hydration group was 6.6% (53/797), while the incidence of CIN in the control (hydration only) group was 20% (165/814). Pooled analysis of all studies showed TMZ reduced incidence of CIN compared to saline hydration alone (OR risk 0.30, 95% CI 0.21, 0.42, P < .0001).ConclusionTMZ added to hydration reduces CIN in renal insufficiency patients undergoing coronary angiography.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

34 keywords...

hide…