• Clinics in chest medicine · Jun 1986

    Review

    Abnormal respiratory epithelial ion transport in cystic fibrosis.

    • M R Knowles, M J Stutts, J R Yankaskas, J T Gatzy, and R C Boucher.
    • Clin. Chest Med. 1986 Jun 1; 7 (2): 285-97.

    AbstractThe respiratory epithelium of cystic fibrosis patients exhibits excessive sodium (and volume) absorption and an absence of chloride (and volume) secretion in response to usual stimuli. These abnormalities likely contribute to the pathophysiology of cystic fibrosis lung disease, and provide a rationale for a novel therapeutic approach to this problem.

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