• Yang-Kai Xu, Fu-Gui Zhu, Er-You Feng, Chao-Ling Fan, Guang-Shu Yu, Yan-Zhen Wei, and Li-Hua Xie.
• Bone Surgery Area, The Second Affiliated Hospital of Xiamen University, Fuzhou 350007, China.
• Zhongguo Zhong Yao Za Zhi. 2018 May 1; 43 (9): 1934-1939.

AbstractTo systematically evaluate the efficacy and safety of external therapies of traditional Chinese medicine(TCM) combined with sodium hyaluronate(SH) injected in articular cavity therapy on knee osteoarthritis(KOA). The following databases such as CNKI, WanFang, VIP, CBM, PubMed and Medline were researched to collect the randomized controlled trails on external therapies of TCM combined with sodium hyaluronate injected in articular cavity therapy on KOA. The selection of studies, assessment of methodological quality and data extraction were performed independently by two researchers. The methodological quality was assessed by using the Cochrane system evaluation methodology and Meta-analysis were performed by using Cochrane Collaboration's the RevMan 5.3 software. Forteen studies involving 1 449 patients were included. All of the trails were not adequate enough in methodological quality. Meta-analysis indicated that compared with control group, external therapies of TCM combined with sodium hyaluronate injected in articular cavity could raise effectiv rate(P<0.000 01) and cure-rate(P<0.000 01), improve Lysholm score(P=0.003) and reduce VAS score(P<0.000 1). But two groups have no difference in Womac score (P=0.13).Compared with the treatment with sodium hyaluronate injected in articular cavity, external therapies of TCM combined with sodium hyaluronate injected in articular cavity, a promising treatment options, can be complementary advantages, improve the clinical curativ effect. But it still needs low risk and high quality clinical trials to verify.Copyright© by the Chinese Pharmaceutical Association.

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