• Rodolfo Mauceri, Denise Murgia, Orazio Cicero, Luigi Paternò, Luca Fiorillo, Viviana De Caro, and Giuseppina Campisi.
• Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127 Palermo, Italy.
• Medicina (Kaunas). 2021 Feb 20; 57 (2).

AbstractThe management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

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