• Rui-Han Zhou, Qian Wang, Xiao-Min Hu, Mei Liu, and An-Ren Zhang.
• School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2021 Apr 16; 100 (15): e25509e25509.

BackgroundFasting and caloric restriction have a potential means of anti-inflammatory, as they can decrease the level of systemic inflammation. Although encouraging results have been obtained in animal experiments, there is no consensus on whether these results are applicable to human. The objective of this systematic review and meta-analysis is to analyze the influence of fasting and caloric restriction on inflammation levels in humans.MethodsThe systematic review and meta-analysis will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. The following eight databases will be searched:(The retrieval time is from the establishment of each database to December 2020): PubMed, the Cochrane Library, Embase, Web of Science, China National Knowledge infrastructure (CNKI), China Biology Medicine (CBM), Wan Fang Data, the Chinese Science and Technology Periodical Database (VIP). Relevant data will be performed by Revman 5.3 software provided (Cochrane Collaboration) and Stata 14.0 statistical software.ResultsThe results of this systematic review and meta-analysis will be published in a peer-reviewed journal.ConclusionsThis systematic review will provide evidence to judge the effectiveness of fasting and calorie restriction in human subjects, so as to provide a sound basis for future research and lifestyle promotion.Inplasy Registration NumberINPLASY202130026.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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