• Biol Res Nurs · Mar 2019

    Are Patients With Fibromyalgia in a Prothrombotic State?

    • Francisco Molina, María Luisa Del Moral, Mercedes La Rubia, Santos Blanco, Ramón Carmona, and Alma Rus.
    • 1 Department of Health Science, University of Jaén, Jaén, Spain.
    • Biol Res Nurs. 2019 Mar 1; 21 (2): 224-230.

    ObjectivesThe aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM).MethodWe carried out a case-control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR).ResultsThe results showed significantly increased fibrinogen levels ( p < .05), platelet count ( p < .05), PDW ( p = .059), RBC count ( p < .05), and PLR ( p < .05) in women with FM versus the healthy volunteers. Prothrombin time ( p < .05) and MPV ( p < .05) were significantly lower in patients with FM than in the controls.ConclusionsElevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombotic state in FM patients, which may be enhanced by an increased inflammatory tone. This prothrombotic state may increase the risk of thrombosis-related cardiovascular disease in patients with FM.

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