• Cornea · Apr 2016

    Case Reports

    Electrical Stimulation of the Trigeminal Ganglion and Intrathecal Drug Delivery Systems for the Management of Corneal Neuropathic Pain.

    • Rony R Sayegh, Jennifer A Sweet, Jonathan P Miller, and Salim M Hayek.
    • *Department of Ophthalmology, University Hospitals Eye Institute, Cleveland, OH; Departments of †Neurological Surgery; and ‡Anesthesiology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH.
    • Cornea. 2016 Apr 1; 35 (4): 576-7.

    PurposeThis case study reports on 2 novel neuromodulatory approaches in the management of a particularly recalcitrant case of corneal neuropathic pain.MethodsReport of a caseResults: A 32-year-old woman presented with intractable bilateral dry eye-like symptoms and corneal neuropathic pain after undergoing laser in situ keratomileusis surgery. Extensive ocular and systemic therapies were unsuccessful. Implantation of an electrode for the electrical stimulation of the trigeminal ganglion resulted in complete resolution of symptoms, but pain recurred after lead migration. Implantation of an intrathecal infusion system for fentanyl and bupivacaine delivery at the C1-C2 level resulted in control of her symptoms with excellent pain relief for more than 1 year.ConclusionsElectrical stimulation of the trigeminal ganglion and a high cervical intrathecal pain pump can be used in the management of corneal neuropathic pain unresponsive to ocular and systemic approaches.

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