• M Chiarugi, P Buccianti, O Goletti, L Decanini, F Sidoti, and E Cavina.
• Dipartimento di Chirurgia, Università degli Studi di Pisa.
• Ann Ital Chir. 1996 Sep 1; 67 (5): 609-13.

Study ObjectiveTo identify factors affecting mortality and morbidity in patients operated on for perforated peptic ulcer.DesignRetrospective analysis.SettingUniversity Hospital, Italy.PatientsForty patients consecutively operated on for perforated peptic ulcer by simple suture procedure performed either by laparotomy (n = 26) or laparoscopic (n = 14) approach.Measurements And Main ResultsMortality was 20% (n = 8) and morbidity in survivors was 25% (n = 8). Compared to survivors, non-survivors were older (mean age 79.3 yrs. vs 60.0 yrs., p < 0.01), had worse APACHE II and SAPS scores (mean 20.1 vs 8.5, p < 0.001; and 13.1 vs. 5.5, p < 0.0001 respectively), were treated later (mean interval from outbreak of symptoms to surgery 30.8 hrs. vs. 11.1 hrs., p < 0.01), and the size of their perforation was larger (mean 15.1 mm. vs. 8.6 mm, p < 0.05). The laparoscopic approach was the only factor that significantly was associated with morbidity in survivors (p < 0.01). The presence of at least two risk factors, enhanced the probability of death.ConclusionOld age, great APACHE II and SAPS scores, delay in treatment and large size of the perforation were associated significantly to mortality in perforated peptic ulcer patients. Efforts should be made perioperatively for patients having these risk factors.

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