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J Clin Psychopharmacol · Feb 1989
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical TrialAlprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks.
- D J Munjack, B Crocker, D Cabe, R Brown, R Usigli, A Zulueta, M McManus, D McDowell, R Palmer, and M Leonard.
- University of Southern California Medical School.
- J Clin Psychopharmacol. 1989 Feb 1; 9 (1): 22-7.
AbstractFifty-five patients completed a 5-week double-blind study comparing alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. There was no concomitant behavioral treatment. Patient and therapist rating scales included Sheehan's Panic and Anxiety Attack Scales, the Marks-Sheehan Phobia Scale, the Hamilton Anxiety Scale, the Hamilton Depression Scale, and the Side Effects Checklist. The results generally support the efficacy of alprazolam, but not propranolol, in the treatment of panic disorder and agoraphobia with panic attacks. The significance of the results are discussed, as well as a number of the unique aspects of our procedures and patient population.
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