• British medical journal · Jun 1969

    Cardiac abnormalities in poisoning with tricyclic antidepressants.

    • J W Freeman, G R Mundy, R R Beattie, and C Ryan.
    • Br Med J. 1969 Jun 7; 2 (5657): 610-1.

    AbstractOf 80 consecutive admissions to a general hospital for drug overdose, 10 had taken one or other of the tricyclic antidepressants. All 10 had abnormalities of cardiac conduction as shown by prolonged Q-T(e) intervals, and eight had S-T segment and T-wave changes. Five of the 10 patients had arrhythmias and two of these died. Continuous electrocardiographic monitoring is recommended in patients with overdosage of tricyclic antidepressants.

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