• Brian H Cuthbertson, Amir R Amiri, Bernard L Croal, Sriram Rajagopalan, Julie Brittenden, and Graham S Hillis.
• Health Services Research Unit, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, United Kingdom. b.h.cuthbertson@abdn.ac.uk
• Am. J. Cardiol. 2007 Oct 15; 100 (8): 1310-3.

AbstractThis study was conducted to assess the ability of preoperative B-type natriuretic peptide levels to predict medium-term mortality in patients who undergo major noncardiac surgery. During a median of 654 days of follow-up, 33 patients from a total cohort of 204 patients (16%) died, 17 from cardiovascular causes. The optimal cutoff in this cohort, determined using a receiver-operating characteristic curve, was >35 pg . ml(-1). This was associated with a 3.5-fold increase in the hazard of death (p = 0.001) and a 6.9-fold increase in the hazard of cardiovascular mortality (p = 0.003). In conclusion, these findings extend recent work demonstrating that B-type natriuretic peptide levels obtained before major noncardiac surgery can be used to predict perioperative morbidity and indicate that they also forecast medium-term mortality, particularly cardiovascular death.

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