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- Marc Bonnefoy, Jocelyne Drai, and Tomasz Kostka.
- Service de médecine gériatrique, Pavillon Michel Perret. CH. Lyon-Sud, 69495 Pierre-Bénite. marc.bonnefoy@chulyon.fr
- Presse Med. 2002 Jul 27; 31 (25): 1174-84.
AbstractFREE RADICALS AND THE THEORY OF AGING: Severe oxidative stress progressively leads to cell dysfunction and ultimately cell death. Oxidative stress is defined as an imbalance between pro-oxidants and/or free radicals on the one hand, and anti-oxidizing systems on the other. The oxygen required for living may indirectly be responsible for negative effects; these deleterious effects are due to the production of free radicals, which are toxic for the cells (superoxide anions, hydroxyl radicals, peroxyl radicals, hydrogen peroxide, hydroperoxides and peroxinitrite anions). Free radical attacks are responsible for cell damage and the targeted cells are represented by the cell membranes, which are particularly rich in unsaturated fatty acids, sensitive to oxidation reactions; DNA is also the target of severe attacks by these reactive oxygen species (ROS).
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