• Nuerbiye Dilixiati, Shuang Sui, Xinmei Ge, Dilihuma Tuerxun, and Ying Huang.
• People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region Province, China.
• Medicine (Baltimore). 2021 May 7; 100 (18): e25573e25573.

BackgroundThe distribution of ABO blood group is related to the incidence of various diseases. Gestational hypertensive disorders (GHD) is one of the most important risk factors during pregnancy, which has certain heredity. It is reported that ABO blood type is associated with the risk of GHD. However, the results are still controversial. In this study, we conducted a systematic review and meta-analysis to clarify the relationship between ABO blood group and GHD.MethodsAll eligible studies come from Embase, Cochrane Library, Pubmed, Chinese databases SinoMed, Chinese National Knowledge Infrastructure, Chinese Scientific Journals Database, and Wanfang Data. The retrieval time is from the establishment of the database to March 2021. The language will be limited to Chinese and English. The 2 reviewers will be responsible for the selection of the study, the extraction of data, and the evaluation of the quality of the research. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 16.0.ResultsThe results of this meta-analysis will be published in peer-reviewed journals.ConclusionThis study will provide evidence to support the relationship between ABO blood group and the risk of GHD.Ethics And DisseminationThe private information from individuals will not be published. This systematic review also will not impair endangering participants' rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.Osf Registration NumberDOI 10.17605/OSF.IO/3X9YZ.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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