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- Robert Goodnough, Adina Badea, Curtis Geier, Kara L Lynch, and Kathy T LeSaint.
- Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas.
- Medicine (Baltimore). 2021 May 7; 100 (18): e25577e25577.
IntroductionBrugada syndrome may be unmasked by non-antiarrhythmic pharmaceuticals or drugs. Lacosamide is an antiepileptic agent with a novel mechanism of sodium channel inhibition and has the potential to cause cardiac sodium channel blockade.Patient ConcernsIn this report, we describe the case of patient with a history of a seizure disorder who presented with Brugada I electrocardiogram morphology in the setting of septicemia.DiagnosisBrugada I electrocardiogram morphology was unmasked by lacosamide antiepileptic monotherapy.InterventionsLacosamide therapy was discontinued.OutcomesNormalization of the electrocardiogram and resolution of Brugada morphology occurred on hospital day 1.ConclusionCaution should be exercised in the use of lacosamide in those at risk for conduction delay, or in combination therapy with medications that impair renal clearance, metabolism of lacosamide, or that display inherent sodium channel blocking properties.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
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