• Medicine · May 2021

    Association between Toll-like receptor gene polymorphisms and risk of Helicobacter pylori infection: A protocol for systematic review and meta-analysis.

    • Xiaocong Ma, Liying Lu, Yan Tang, Weisheng Luo, Jianxiang Li, and Meiwen Tang.
    • Graduate School, Guangxi University of Chinese Medicine.
    • Medicine (Baltimore). 2021 May 7; 100 (18): e25729e25729.

    BackgroundThere were many case-control studies performed the association between TLRs gene polymorphisms and the correlation of Helicobactor pylori infection, these results were inconformity. Therefore, a comprehensive meta-analysis was performed to evaluate the TLRs gene polymorphism and susceptibility to H. pylori infection.MethodsEligible studies were searched from PubMed, EMBASE, Web of science, Cochrane library, CNKI, CBM, Wan Fang Database and VIP Database, all the databases were searched from inception to December 2020. OR with the corresponding 95% CI were presented as associations between certain TLR gene polymorphism and the risk of H. pylori infection, all the included data will be analyzed with the software of Review Manager 5.2 and STATA 14.2.ResultsThis study will provide a high-quality evidence to find the TLR gene polymorphisms with H. pylori infection susceptibility.ConclusionThis study will explore which TLR genotype increase the risk of H. pylori infection.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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