• Guanyu Hu, Hongshi Zhang, Yufeng Wang, and Deyu Cong.
• Changchun University of Chinese Medicine, Changchun, China.
• Medicine (Baltimore). 2021 May 7; 100 (18): e25788e25788.

BackgroundPost-stroke spasticity (PSS) is a major worldwide health problem, and timely and effective rehabilitation is associated with the risk of diabetes development; there are a variety of non-pharmacological interventions applied to the rehabilitation of PSS in these treatments; however, the relative efficacy and safety of different therapies remain uncertain, and we will conduct a systematic review and network meta-analysis to evaluate different non-pharmacological interventions. The relative efficacy and safety of intervention in PSS rehabilitation, thus providing evidence to support the optimization of the PSS rehabilitation program.MethodsWe searched the following databases electronically, including four English literature databases (i.e., PubMed, Medline, Embase, and Cochrane Library) and two Chinese literature databases (i.e., China National Knowledge Infrastructure and VIP). We will also search for randomized controlled trials on non-pharmacological interventions for post-stroke spasticity, and the search time limit is from its establishment to May 2020. Two reviewers working independently will screen the titles, abstracts, and full papers. Data extraction will be completed by two independent authors. The primary outcome was the motor function. The secondary outcome was the assessment of daily living ability. We will use RevMan V.5.3 software to compute the data synthesis carefully when a meta-analysis is allowed. We will conduct Bayesian network meta-analysis using the Markov Chain Monte Carlo random effects model in Aggregate Data Drug Information System version 1.16.8 (Drugis, Groningen, NL).ResultsThis study provides a high-quality synthesis to assess the effectiveness and safety of non-pharmacological interventions for patients with PSS.ConclusionThe results of this study will provide evidence to judge whether non-pharmacological interventions are effective interventions for patients with post-stroke spasticity.Ethics And DisseminationThe results of this meta-analysis and meta-regression will be disseminated through publication in a peer-reviewed journal and presented at a relevant conference. The data used in the network meta-analysis did not contain individual patient data. Therefore, ethical approval was not required.Inplasy Registration NumberINPLASY202140059.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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