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- Pamela I Good and Thomas A Hooven.
- Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH-17, New York, NY 10032, USA.
- Pediatr. Clin. North Am. 2019 Apr 1; 66 (2): 321-331.
AbstractEarly-onset sepsis (EOS) is an important cause of neonatal morbidity. Despite extensive study, identifying at-risk newborns remains challenging, especially if they are initially well appearing. Existing official EOS recommendations suggest a conservative approach that likely results in overtreatment of a low-risk population. Recent studies indicate that more precise risk assessment and alternative management strategies could decrease the number of infants exposed to blood draws and antibiotics during evaluations for EOS. This article reviews existing guidelines and provides an overview of the Bayesian sepsis calculator and serial observation as an alternative to laboratory studies and empirical antibiotics.Copyright © 2018 Elsevier Inc. All rights reserved.
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