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- D Clarke, I Gorman, F Ringholz, M McDermott, D W Cox, P Greally, B Linnane, and P Mc Nally.
- National Children's Research Centre, Crumlin, Dublin 12, Ireland.
- Resp Res. 2018 Dec 17; 19 (1): 255.
AbstractPulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.
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