• Hee Jeong Cho, Jin Ho Baek, Dong Won Baek, Byung Woog Kang, Soo Jung Lee, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu Seog Choi, and Jong Gwang Kim.
• Department of Oncology/Hematology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea.
• In Vivo. 2019 Nov 1; 33 (6): 1959-1965.

Background/AimThis study evaluated clinicopathological and molecular features and their prognostic impact on patients with locally advanced rectal cancer (LARC) who received preoperative chemoradiotherapy (CRT).Patients And MethodsWe retrospectively gathered data from 284 patients with LARC who underwent total mesorectal excision (TME) after CRT.ResultsIn the univariate analysis, lower yield pathologic T (ypT) category, yield pathologic N (ypN) category, yield pathologic TNM (ypTNM) stage, as well as the absence of lymphovascular invasion (LVI) and perineural invasion (PNI), were significantly associated with better disease-free survival (DFS) and overall survival (OS). Meanwhile, the expression of Ki-67, p53, and the mismatch repair (MMR) status showed no association with clinical outcomes. A multivariate survival analysis revealed that ypT category and LVI were independent prognostic factors of a worse DFS (HR=3.081, p-value=0.001; HR=2.818, p-value=0.030) and OS (HR=3.158, p-value=0.006; HR=3.837, p-value=0.014).ConclusionThe ypT category and the presence of LVI were found to be prognostic factors for patients with LARC after CRT followed by TME.Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

24 keywords...

hide…