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The Journal of infection · Nov 2005
Case ReportsClindamycin in the treatment of group G beta-haemolytic streptococcal infections.
- A Pillai, S Thomas, and C Williams.
- Dumfries and Galloway Royal Infirmary, Dumfries, DG1 4AP, UK.
- J. Infect. 2005 Nov 1; 51 (4): e207-11.
AbstractWe report a case of severe streptococcal cellulitis in a healthy 47 year old male, where the sole microbial isolate was a beta-haemolytic group G Streptococcus. Treatment failure with high dose penicillin was observed despite in vitro sensitivity. The addition of clindamycin resulted in dramatic clinical improvement. This may indicate an Eagle-type effect (whereby antibiotics exhibit paradoxically reduced bactericidal activities at high drug concentrations), in group G beta-haemolytic infections. Although well documented with group A streptococcal infections, this phenomenon has not been fully recognised with group G beta-haemolytic streptococcal infections. This may have important implications for clinical management.
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