• Pediatr. Clin. North Am. · Oct 2017

    Review

    Immunoparalysis in Pediatric Critical Care.

    • Mark W Hall, Kristin C Greathouse, Rajan K Thakkar, Eric A Sribnick, and Jennifer A Muszynski.
    • Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA. Electronic address: mark.hall@nationwidechildrens.org.
    • Pediatr. Clin. North Am. 2017 Oct 1; 64 (5): 1089-1102.

    AbstractAlthough many forms of critical illness are initiated by a proinflammatory stimulus, a compensatory anti-inflammatory response can occur with systemic inflammation. Immunoparalysis, an important form of acquired immunodeficiency, affects the innate and adaptive arms of the immune system. Immunoparalysis has been associated with increased risks for nosocomial infection and death in a variety of pediatric critical illnesses. Evidence suggests that immunoparalysis is reversible with immunostimulants. Highly standardized, prospective immune monitoring regimens are needed to better understand the immunologic effects of critical care treatment regimens and to enrich clinical trials with subjects most likely to benefit from immunostimulatory therapies.Copyright © 2017 Elsevier Inc. All rights reserved.

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