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Expert Rev Respir Med · Jun 2016
ReviewNewer developments in idiopathic pulmonary fibrosis in the era of anti-fibrotic medications.
- Girish B Nair, Ajsza Matela, Daniel Kurbanov, and Ganesh Raghu.
- a Division of Pulmonary & Critical Care Medicine , Winthrop-University Hospital , Mineola , NY , USA.
- Expert Rev Respir Med. 2016 Jun 1; 10 (6): 699-711.
AbstractIdiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease with a fatal prognosis. Over the last decade, the concepts in pathobiology of pulmonary fibrosis have shifted from a model of chronic inflammation to dysregulated fibroproliferative repair in genetically predisposed patients. Although new breakthrough treatments are now available that slow the progression of the disease, several newer anti-inflammatory and anti-fibrotic drugs are under investigation. Patients with IPF often have coexistent conditions; prompt detection and interventions of which may improve the overall outcome of patients with IPF. Here, we summarize the present understanding of pathogenesis of IPF and treatment options for IPF in the current landscape of new anti-fibrotic treatment options.
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