• Keisuke Kidoguchi, Yasushi Kubota, Shun Fujimoto, Yasuhisa Sakata, Haruna Kizuka-Sano, Kyosuke Yamaguchi, Hiroshi Ureshino, Hiroo Katsuya, Toshihiko Ando, Motohiro Esaki, and Shinya Kimura.
• Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
• Intern. Med. 2021 Jan 1; 60 (10): 160116051601-1605.

AbstractCronkhite-Canada syndrome (CCS) is a rare polyposis disorder accompanied by alopecia and onychodystrophy. A 63-year-old man with a history of CCS and repeated embolism developed progressive thrombocytopenia and mild anemia. Laboratory testing, a bone marrow examination, and magnetic resonance imaging of the spine resulted in a diagnosis of concurrent aplastic anemia (AA). Paroxysmal nocturnal hemoglobinuria (PNH)-type cells were detected in a peripheral blood specimen. In addition, human leukocyte antigen (HLA) included DRB1*15:01 and DRB1*15:02. Mesalazine was discontinued in consideration of possible drug-induced pancytopenia. Immunosuppressive therapy ameliorated both the gastrointestinal symptoms of CCS and pancytopenia. A common autoimmune abnormality might underlie both CCS and AA.

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