• Meng Meng, Guanyu Hu, Kang Yang, Heran Wang, Yiran Han, Ting Pan, Huijuan Lou, Ye Zhang, Yufeng Wang, and Deyu Cong.
• Department of Acupuncture and Tuina, Changchun University of Chinese Medicine.
• Medicine (Baltimore). 2021 May 21; 100 (20): e26013e26013.

BackgroundPost-stroke depression (PSD) is the most common mental health issue, affecting approximately 33% of stroke survivors. Tuina and acupuncture treatments are often combined to treat PSD; however, there has been no meta-analysis on their synergistic effect. Therefore, we aimed to perform a systematic review and meta-analysis to estimate the effectiveness of Tuina and acupuncture in PSD treatment.MethodsThe following electronic databases will be searched: PubMed, the Cochrane Library, Embase, Web of Science, Medline, CNKI, Chinese Biomedical Literature Database, VIP, and Wan Fang databases. We will consider articles published between database initiation and April 2021. Clinical randomized controlled trials related to Tuina combined with acupuncture for post-stroke depression will be included in the study. Language is limited to Chinese and English. Research selection, data extraction, and research quality assessment were independently completed by 2 researchers. Data were synthesized using a fixed effect model or random effect model, depending on the heterogeneity test. The Hamilton depression rating scale (HDRS) and effective rate were the primary outcomes. The post-stroke depression rating scale (PSDRS), patient health questionnaire-9 (PHQ-9), and the incidence of adverse events will also be assessed as secondary outcomes. RevMan V.5.4 statistical software will be used for meta-analysis. If it is not appropriate for a meta-analysis, a descriptive analysis will be conducted. Data synthesis uses the risk ratio and the standardized or weighted average difference of continuous data to represent the results.ResultsThis study provides a high-quality synthesis to assess the effectiveness and safety of Tuina for post-stroke depression.ConclusionThis systematic review will provide evidence to determine whether Tuina plus acupuncture is an effective and safe intervention for patients with post-stroke depression.Ethics And DisseminationThe protocol of the systematic review does not require ethical approval because it does not involve humans. This article will be published in peer-reviewed journals and presented at relevant conferences.Systematic Review RegistrationINPLASY202140098.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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