• Pediatr Crit Care Me · Jan 2005

    Case Reports

    Long-term treatment of plastic bronchitis with aerosolized tissue plasminogen activator in a Fontan patient.

    • Martin K Wakeham, Andrew H Van Bergen, Luis E Torero, and Javeed Akhter.
    • Pediatric Critical Care, Advocate Hope Children's Hospital, Oak Lawn, IL 60453, USA. wakehamdoc@aol.com
    • Pediatr Crit Care Me. 2005 Jan 1; 6 (1): 76-8.

    ObjectiveTo report the successful treatment of plastic bronchitis with aerosolized tissue plasminogen activator.DesignCase report.PatientsA 4-yr-old boy with congenital heart disease, who developed plastic bronchitis 33 months after a Fontan operationInterventionsLong-term treatment with aerosolized tissue plasminogen activator.Measurements And Main ResultsWe describe the case of a boy who developed recurrent episodes of life-threatening airway obstruction secondary to plastic bronchitis. Following the failure of multiple therapeutic interventions, his condition improved significantly with aerosolized tissue plasminogen activator. Several attempts to wean him off this treatment resulted in clinical deterioration. He has remained on long-term aerosolized tissue plasminogen activator.ConclusionTreatment of plastic bronchitis with aerosolized tissue plasminogen activator may benefit patients in whom other therapies have failed.

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