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J. Clin. Microbiol. · Apr 2004
DNA polymorphism assay distinguishes isolates of Leishmania donovani that cause kala-azar from those that cause post-kala-azar dermal Leishmaniasis in humans.
- Gannavaram Sreenivas, B V Subba Raju, Ruchi Singh, Angamuthu Selvapandiyan, Robert Duncan, Dwijen Sarkar, Hira L Nakhasi, and Poonam Salotra.
- Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India.
- J. Clin. Microbiol. 2004 Apr 1; 42 (4): 1739-41.
AbstractLeishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.
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