• Lauren J White, Ryan Fredericks, Candace N Mannarino, Stephen Janofsky, and Faustino Edward Vincent S EVS Department of Pediatrics, Yale School of Medicine, New Haven, CT. Electronic address: vince.faustino@yale.edu..
• Department of Pediatrics, Yale-New Haven Children's Hospital, New Haven, CT.
• J. Pediatr. 2017 May 1; 184: 114-119.e6.

ObjectiveTo determine the epidemiology of bleeding in critically ill children.Study DesignWe conducted a cohort study of children <18 years old admitted to the pediatric intensive care unit for >24 hours and without clinically relevant bleed (CRB) on admission. CRB was defined as resulting in severe physiologic derangements, occurring at a critical site or requiring major therapeutic interventions. Using a novel bleeding assessment tool that we developed, characteristics of the CRB were abstracted from the medical records independently and in duplicate. From the cohort, we matched each child with CRB to 4 children without CRB based on onset of CRB. Risk factors and complications of CRB were identified from this matched group of children.ResultsWe analyzed 405 children with a median age of 35 months (IQR 7-130 months). A total of 37 (9.1%) children developed CRB. The median number of days with CRB was 1 day (IQR 1-2 days). Invasive ventilation (OR 61.35; 95% CI 6.27-600.24), stress ulcer prophylaxis (OR 2.70; 95% CI 1.08-6.74), surgical admission (OR 0.29; 95% CI 0.10-0.84), and aspirin (OR 0.04; 95% CI 0.002-0.58) were associated with CRB. CRB was associated with longer time to discharge from the unit (hazard ratio 0.20; 95% CI 0.13-0.33) and the hospital (hazard ratio 0.49; 95% CI 0.33-0.73). Children with CRB were on vasopressor longer and transfused more red blood cells after the CRB than those without CRB.ConclusionsOur findings suggest that bleeding complicates critical illness in children.Copyright © 2017 Elsevier Inc. All rights reserved.

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