• Hai-Ying Dai, Fang Hu, and Yuan Ding.
• Department of Clinical Laboratory, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Edong Healthcare Group, Huangshi.
• Medicine (Baltimore). 2021 May 28; 100 (21): e25981e25981.

BackgroundOvarian carcinoma (OC) is considered among the most prevalent triggers of cancer-related deaths in women. Many studies have demonstrated that human epididymis protein 4 (HE-4) as well as cancer antigen 125 (CA-125) are over-expressed in various malignant tumors, such as lung, liver, endometrial, gastric, breast, as well as ovarian cancers. Nonetheless, the overall diagnostic value of serum HE-4, in addition to CA-125 n patients experiencing OC, is still largely undetermined. Therefore, the current study intends to investigate the general diagnostic significance of HE-4 along with CA-125 in patients with OC.MethodsWe aim to systematically search retrospective or prospective study for potential eligible studies from electronic databases, such as MEDLINE, EMBASE, Cochrane Library, Web of Science, as well as Chinese National Knowledge Infrastructure. We will relevant articles evaluating the general diagnostic significance of HE-4 and CA-125 in patients with OC from these databases. We will define our search in English and Chinese. Likewise, we will use 2 independent authors to extract the required data, using the Quality Assessment of Diagnostic Accuracy Studies-2 tool to evaluate he procedural quality of all included literature. We will use the appropriate statistical method to complete data analyses.ResultsThe present study aims to investigate the general diagnostic significance of HE-4 and CA-125 in patients suffering from OC.ConclusionThe present study will systematically summarise current evidence of HE-4 in combination with CA-125 in relation to diagnosing OC.Ethics And DisseminationEthical approval will not be required.Protocol Registration NumberDOI 10.17605/OSF.IO/YQPC7 (https://osf.io/yqpc7/).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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