• Rui Gu, Yao Xiong, Li Li, Xiaoling Zhao, and Yan Liu.
• Department of Neurology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan Province, China.
• Medicine (Baltimore). 2021 May 28; 100 (21): e26082e26082.

RationaleThalassemia is an inherited disease associated with thromboembolic events (TEE) and cerebral artery disease. Here, we report a patient with beta-thalassemia presenting with intracerebral hemorrhage due to cerebral venous sinus thrombosis (CVST), and intracranial aneurysms were found after examination. We believe that it is very rare for this patient to have two kinds of cerebrovascular diseases.PatientsconcernA 25-year-old woman suffered from headache for nine days. She had a history of thalassemia and splenectomy nine years prior.DiagnosisIntracranial hemorrhage, Cerebral venous sinus thrombosis, Intracranial aneurysm and double heterozygous beta-thalassemia major.InterventionsThe patient was treated with low-molecular-weight heparin sodium injection (4100IU sc q12 h) and then switched to warfarin after four days of overlap with low-molecular-weight heparin sodium injection. Oral hydroxyurea was prescribed before discharged from the hospital.OutcomesThe patient's headache was relieved significantly within 48 h, and re-examination of CT showed that the hemorrhage was completely absorbed one week later.LessonsCVST and intracranial aneurysms are associated with the pathological mechanism of thalassemia, and patients with beta-thalassemia should be monitored and educated for long-term prevention, especially those with risk factors.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

38 keywords...

hide…