• Lei He, Zhiwei Xue, Yijun Liu, Ruixin Chen, and Shu Zhou.
• Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu.
• Medicine (Baltimore). 2021 May 28; 100 (21): e26106e26106.

BackgroundThere is limited study that has conducted a review investigating the clinical effects of vitamin and omega-3 fatty acid co-supplementation on blood glucose in women with gestational diabetes mellitus (GDM). Therefore, in order to provide new evidence-based medical evidence for clinical treatment, we undertook a systematic review and meta-analysis to assess the effectiveness and safety of vitamin and omega-3 fatty acid co-supplementation on blood glucose in women with GDM.MethodsThis protocol was written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement guidelines. We will conduct systematic reviews and meta-analyses to identify relevant randomized controlled trials (RCTs) involving vitamin and omega-3 fatty acid co-supplementation on GDM in electronic databases including PubMed, Web of Science, Embase, and the Cochrane Library up to June 2021. Exclusion criteria include observational studies, non-RCTs, review articles, studies with a sample size <50, and studies with insufficient outcome data. The primary outcomes include fasting glucose and insulin. Secondary outcomes are evaluated in a homeostasis model of insulin resistance, total antioxidant capacity, triglycerides, total cholesterol, low-density lipoprotein cholesterol, preterm birth and macrosomia over 4 kg.ResultsThe review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.Registration Number10.17605/OSF.IO/NSW54.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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