• Ting Pan, Xue Zhou, Xuefeng Li, Heran Wang, Meng Meng, Yiran Han, Xin Qian, Chunhai Chen, and Xinhua Chen.
• Department of Acupuncture and Tuina, Changchun University of Chinese Medicine.
• Medicine (Baltimore). 2021 May 28; 100 (21): e26115e26115.

BackgroundWith the aging of society, the incidence of type 2 diabetes (T2DM) is increasing every year, and there is a clear correlation between T2DM and cognitive dysfunction. Acupuncture therapy has been widely used in the treatment of T2DM, but there is no systematic review on the treatment of T2DM associated with cognitive impairment. Therefore, this study aimed to conduct a meta-analysis of acupuncture in the treatment of T2DM with cognitive impairment to clarify its efficacy.MethodsA structured and systematic literature search will be conducted in the following databases up to April 26, 2021: PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science (WOS), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Scientific and Journal Database (VIP), and Wan Fang database (Wanfang). We will use the Review Manager 5.4 software provided by the Cochrane Collaborative Network for statistical analysis. We then assessed the quality and risk of the included studies and observed the outcome measures.ResultsThis meta-analysis further determined the beneficial effects of acupuncture on T2DM with cognitive impairment.ConclusionThe purpose of this meta-analysis was to explore the effect of acupuncture on patients T2DM with and cognitive impairment patients, and provide more options for clinicians and patients to treat T2DM with cognitive impairment.Ethics And DisseminationThis systematics review will evaluate the efficacy and safety of acupuncture in the treatment of T2DM with cognitive impairment. Since all the data included were published, the systematic review did not require ethical approval.Registration NumberCRD42021245681.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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