• Yuzhu Hou, Xuejiao Hu, Yixing Duan, Wubin Tan, and Xi Guo.
• Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, PR China.
• Medicine (Baltimore). 2021 May 28; 100 (21): e26142e26142.

RationaleA seminal vesicle cyst is a benign lesion of the seminal vesicle that is usually asymptomatic. However, when a giant seminal vesicle cyst ruptures and bleeds, it can cause obvious clinical symptoms. To our knowledge, no single giant seminal vesicle cyst with hemorrhage has been reported in current studies, and surgery is the primary method to treat seminal vesicle hemorrhage with obvious symptoms.Patient ConcernsA 31-year-old man presented with urination pain but without obvious urination frequency and urgency, dysuria, and discomfort. Rectal palpation in the chest-knee position revealed a hard mass palpable in the upper right with a smooth surface and mild tenderness, and the upper edge of the mass could not be palpated.DiagnosisThe results of the B-mode ultrasound indicated a mixed echogenic lump between the bladder and prostate, with a size of 81 × 76 mm. The computer tomography scan showed an "S" tubular lump in the right side of the pelvic cavity. The mass has a computer tomography value of 58 to 70 HU, and uneven reinforcement can be observed. On the basis of the results of the magnetic resonance imaging of the urinary bladder, the lump has T1 and T2 signals of equal lengths.InterventionsThe patient was diagnosed with a huge right seminal vesicle cyst with hemorrhage and was treated via laparoscopic surgery.OutcomesThe patient recovered quickly after the operation, and the symptoms of urination pain were significantly improved.LessonsSeminal vesicle hemorrhage is clinically rare, and laparoscopic treatment is an effective and safe surgical method for the treatment of seminal vesicle cysts.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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