• Xiaodong Li and Hongfa Peng.
• Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
• Medicine (Baltimore). 2021 May 28; 100 (21): e26145e26145.

RationaleChoriocarcinoma is a highly aggressive tumor. It occurs infrequently during pregnancy. The management of choriocarcinoma during pregnancy poses several challenges.Patient ConcernsAt 34 weeks of gestation, a 21-year-old primigravida was transferred to the emergency room for cephalgia, reduced fetal movements, and left intra-atrial intracavitary thrombus.DiagnosisChoriocarcinoma in the third trimester with lung and brain metastases, pulmonary vein thrombosis (PVT), and systemic thrombosis.InterventionAn emergency cesarean section was performed. Subsequently, low-molecular-weight heparin anticoagulation combined with multiagent chemotherapy was administered.OutcomeA 1.59 kg live female was born. Multiagent chemotherapy combined with anticoagulation led to complete regression of the cerebral and pulmonary lesions and the dissolution of pulmonary vein thrombus. At the 11-month follow-up, the patient remained in complete remission without complications, and her child was disease-free.LessonsThis is the first case of gestational choriocarcinoma with PVT. Our case suggests that conservative therapy can be the first choice for small, asymptomatic PVT secondary to choriocarcinoma.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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