• Auris, nasus, larynx · Dec 2005

    Case Reports

    Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate.

    • Alexandros D Karatzanis, Emmanouil I Drivas, Elpida S Giannikaki, Vasilios A Lachanas, John K Hatziioannou, and George A Velegrakis.
    • Department of Otorhinolaryngology, University of Crete School of Medicine, Heraklion, Crete, Greece.
    • Auris Nasus Larynx. 2005 Dec 1; 32 (4): 435-7.

    AbstractMalignant myoepithelioma is a rare salivary gland neoplasm that can arise either de novo or within a pre-existing pleomorphic adenoma. We report a case of malignant myoepithelioma arising from a pleomorphic adenoma of the soft palate. A 70-year-old woman presented in our department with a very large tumor of the soft palate. The patient had a history of a pleomorphic adenoma at the same location that was surgically removed 2 years ago. A second operation, with intraoral excision of the tumor was performed. Histological examination of the recurrence revealed a malignant spindle cell neoplasm with an infiltrative growth pattern and a high mitotic rate. Immunohistochemical investigation confirmed the diagnosis of a low-grade carcinoma of myoepithelial origin with free surgical margins. The patient remains free of disease for more than twelve months after the end of treatment.

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