Pharmacogenetics and Personalized Medicine in Pain

Clin. Lab. Med. · Sep 2016

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Pharmacogenetics and Personalized Medicine in Pain Management.

Genetic research heralds a new therapeutic approach to pain management. Increasing literature demonstrates individual genetic vulnerabilities to specific pain types and mechanisms, partially explaining differing responses to similar pain stimuli. ⋯ Family history and genotyping promise to play an important role in the future approach to pain therapies. As advances continue in the genetics of pain and analgesia, pharmacotherapy will depend more on an individualized, targeted approach and less on empiricism.

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- Lynn R Webster and Inna Belfer.
- Scientific Affairs, PRA Health Sciences, 3838 South 700 East, Suite 202, Salt Lake City, UT 84106, USA. Electronic address: lrwebstermd@gmail.com.
- Clin. Lab. Med. 2016 Sep 1; 36 (3): 493-506.
AbstractGenetic research heralds a new therapeutic approach to pain management. Increasing literature demonstrates individual genetic vulnerabilities to specific pain types and mechanisms, partially explaining differing responses to similar pain stimuli. Furthermore, analgesics demonstrate great variability among carriers of different genotypes. Family history and genotyping promise to play an important role in the future approach to pain therapies. As advances continue in the genetics of pain and analgesia, pharmacotherapy will depend more on an individualized, targeted approach and less on empiricism.Copyright © 2016 Elsevier Inc. All rights reserved.

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